Gene information
Official symbol SPP1
Official full name secreted phosphoprotein 1
Gene type protein-coding gene
Chromosome4q22.1
Alias symbolBSPI; ETA-1
Previous symbolBNSP; OPN
Gene familyReceptor ligands; SIBLING family
Resources
Entrez Gene 6696
HGNC HGNC:11255
Ensembl ENSG00000118785
Vega OTTHUMG00000130599
UCSC uc003hrc.4
GO terms: 67 records
GO Description Category LogP Number of genes Detail
GO:0001503 ossification GO Biological Processes -16.3087139 28 More
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001649 osteoblast differentiation GO Biological Processes -6.81659337 21 More
GO:0001890 placenta development GO Biological Processes -8.66149584 25 More
GO:0001893 maternal placenta development GO Biological Processes -4.28720299 8 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0007566 embryo implantation GO Biological Processes -9.99023740 10 More
GO:0007584 response to nutrient GO Biological Processes -29.4823239 48 More
GO:0008361 regulation of cell size GO Biological Processes -4.6524989 21 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010721 negative regulation of cell development GO Biological Processes -6.74707916 25 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031214 biomineral tissue development GO Biological Processes -8.35916144 12 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032535 regulation of cellular component size GO Biological Processes -4.60941253 33 More
GO:0033273 response to vitamin GO Biological Processes -22.1296854 31 More
GO:0033280 response to vitamin D GO Biological Processes -11.9382575 14 More
GO:0033574 response to testosterone GO Biological Processes -7.37064762 8 More
GO:0034103 regulation of tissue remodeling GO Biological Processes -21.5631413 32 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045124 regulation of bone resorption GO Biological Processes -6.02130395 7 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045926 negative regulation of growth GO Biological Processes -11.4342361 38 More
GO:0046697 decidualization GO Biological Processes -4.51081372 7 More
GO:0046850 regulation of bone remodeling GO Biological Processes -7.11509809 13 More
GO:0046887 positive regulation of hormone secretion GO Biological Processes -9.61661717 24 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048545 response to steroid hormone GO Biological Processes -20.1914989 32 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048640 negative regulation of developmental growth GO Biological Processes -7.44784067 20 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050770 regulation of axonogenesis GO Biological Processes -3.56457741 17 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050840 extracellular matrix binding GO Molecular Functions -6.18341292 8 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0060135 maternal process involved in female pregnancy GO Biological Processes -5.36863544 12 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0061387 regulation of extent of cell growth GO Biological Processes -3.21598264 13 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0110148 biomineralization GO Biological Processes -9.16361193 13 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:1901654 response to ketone GO Biological Processes -10.4509771 32 More
GO:1901655 cellular response to ketone GO Biological Processes -4.22081481 14 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
KEGG pathways: 6 records
KEGG Description Category LogP Number of genes Detail
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04371 Apelin signaling pathway KEGG Pathway -6.49715749 12 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa04512 ECM-receptor interaction KEGG Pathway -16.8587083 28 More
hsa04620 Toll-like receptor signaling pathway KEGG Pathway -11.1460554 15 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
Drug-Gene interaction
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Related drugs: 6 records
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
osteopontin proteomics left ventricular remodeling[prognosis (bad)] old anterior ST elevation myocardial infarction Tamura A et al. Circ J. 2003
osteopontin proteomics left ventricular ejection fraction[other] acute anterior myocardial infarction Suezawa C et al. J Lab Clin Med. 2005
osteopontin proteomics left ventricular end-systolic volume[other] acute anterior myocardial infarction Suezawa C et al. J Lab Clin Med. 2005
osteopontin proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Okyay K et al. Acta Cardiol. 2011
osteopontin proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Meng L et al. Beijing Da Xue Xue Bao Yi Xue Ban. 2013
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